Cardiovascular Metabolism
The importance of cardiovascular metabolism
Advances in technology for measuring cell metabolism has transformed the landscape for assessing cellular bioenergetics in cardiovascular health and disease. Cellular metabolic profiling demonstrates that mitochondrial respiration is predominant in supplying the majority of energy required by cardiomyocytes under baseline conditions. However, cardiomyocytes possess the versatility to switch between, or use both, glycolysis and mitochondrial respiration to sustain their energetic demands under different stresses and environments. XF analysis is improving our understanding of metabolic drivers in cardiomyocytes, helping to identify and expose metabolic phenotypes that associate with cardiovascular health and disease.
Combining years of technical know-how in XF analysis with cellular bioenergetics expertise, we offer fee-for service assays to measure real-time kinetic functional behaviours of live cells, providing our clients with a complete picture of cellular processes as they happen.
Explore more with our sensitive XF compatible metabolism assays
Reveal critical pathways and drug target identification and validation for cardiovascular disease.
Explore cardio-safety, cardiotoxicity, and drug screening to test both efficacy and mitochondrial toxicity of new therapeutic approaches.
Cardiac-embryonic and induced-pluripotent stem cell disease modelling for preclinical safety assessment of compounds.
Use real-time metabolic profiling to phenotype and quality control the manufacturing of induced-pluripotent stem cell derived cardiomyocytes.
Our cardiovascular cell metabolism assays
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BioCELL mitoTOX
Probe real-time, direct measurements of mitochondrial metabolism with high sensitivity and specificity. Our solution for high-throughput compound screening.
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BioCELL proFILE
An all-in-one solution to metabolically profile cells using real-time measurements of mitochondrial and glycolytic energy metabolism.
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BioCELL mitoTEST
This assay provides key insights into mitochondrial function and used to investigate functional differences among cell types, drug candidates, and genetic or biochemical interventions.
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BioCELL glycoTEST
A precise measure of glycolysis in living intact cells, revealing transient responses and rapid metabolic switches not discernible in end-point lactate assays.