Cellular Metabolism in Early Drug Discovery
Advance your preclinical discovery with our cellular metabolic profiling services
The landscape of therapeutic discovery is rapidly evolving, and cellular metabolism has emerged as the critical driver of a range of common diseases. Cell biology functions as a network of signalling, pathways, and checkpoints, with cellular metabolism as a central orchestrator to fuel many cellular processes.
The development of safe and effective drugs requires an understanding of genes, proteins, and pathways that may be key intermediates and potential candidates for drug target intervention. Cellular processes are dynamic, and metabolic programs are the upstream determinants of cellular outcomes. Identification and validation of potential drug targets requires a comprehensive view of those upstream drivers that modulate cell response to safely and effectively intervene.
We provide sensitive assay solutions in cellular metabolism by probing real-time bioenergetics using extracellular flux (XF) technology. XF analysis provides functional, real-time live-cell metabolic measurements for a direct measure and deeper understanding of cellular processes. Our assays can simplify your workflow and interpretation by measuring key indicators of cellular metabolic drivers. Using our technical-know-how from over 12 years experience using XF analysis we support our drug discovery and development clients with metabolism assays to assess disease modelling, metabolic phenotyping, target identification and validation, mechanism of action, and lead discovery.
How can real-time cellular metabolism services and assays support your drug discovery project
Advantages of adopting cellular metabolism in early drug discovery
- Understand the metabolic phenotype of your cell models
- Identify drug targets
- Restore cell health
- Enhance therapeutic performance
- Eliminate compounds early in the discovery process
Why use our assays to support your discovery pipeline?
Cellular metabolism is complex and measurements of cellular bioenergetics require expert knowledge and understanding to design optimal experiments, achieve maximal potential and generate meaningful insights. With over 12 years experience in XF technology, we value the complexity and importance of gaining reproducible and reliable measurements of cellular metabolism. Using our expertise and technical know-how, our assays can help researchers and industry clients discover essential metabolic pathways in their discovery pipeline with support from bioenergetic experts.
Disease areas already benefiting from cell metabolism measurements in early drug discovery
- Neuro-degeneration and aging
- Immunology research and immunotherapy development
- Cancer research and therapy development
- Stem cell differentiation and regenerative medicine
Identify new drug targets
Drug target identification is key in the discovery and development of safe and effective therapies. Often thought of as simply providing ‘housekeeping’ functions, energy metabolism is emerging as a critical contributor to many cellular functions. Dysfunctional metabolism is also associated with a growing number of different disease states. Therefore, looking at the genes, proteins, and pathways that modulate energy metabolism is a promising new avenue for developing novel therapeutic strategies for a broad range of diseases.
Key targets in drug discovery.
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Oncogene pathways
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Nutrient transport and utilisation
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Engineered immune cell fitness and function
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Mitochondrial proteins and intermediates
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Substrate uptake and utilisation proteins
Our cell metabolism assays
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BioCELL mitoTOX
Probe real-time, direct measurements of mitochondrial metabolism with high sensitivity and specificity. Our solution for high-throughput compound screening.
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BioCELL proFILE
An all-in-one solution to metabolically profile cells using real-time measurements of mitochondrial and glycolytic energy metabolism.
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BioCELL mitoTEST
This assay provides key insights into mitochondrial function and used to investigate functional differences among cell types, drug candidates, and genetic or biochemical interventions.
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BioCELL glycoTEST
A precise measure of glycolysis in living intact cells, revealing transient responses and rapid metabolic switches not discernible in end-point lactate assays.