Immune Metabolism
Explore immune cell function in real-time
Metabolic programs are upstream determinants of immune cell outcomes, including activation, proliferation, and memory development. Immune cell function is driven by metabolic reprogramming, which can be modulated to alter performance. Advances in methodology and extracellular flux (XF) technology is helping our clients develop a deeper understanding of the function of immune cells.
Combining years of technical know-how in XF analysis with cellular bioenergetics expertise we offer fee-for service assays to measure real-time kinetic functional behaviours of live immune cells, providing our clients with a complete picture of cellular processes as they happen.
Use our services to investigate:
Immune cell life cycle, lineage, and fitness
Real-time activation
Metabolic demands and fuels
Metabolic signalling and pathways
Modulation to control outcome
Learn how XF analysis is advancing immune cell metabolism
Metabolically profile and phenotype based on immune cell metabolism and function
Real-time metabolic profiling provides a sensitive measure to assess how immune cells adapt in response to changes in substrate supply and energetic demand associated with immune stimulation. We support our clients with questions relating to inflammation, autoimmunity, and immunosuppression, substrate dependencies and the immunosuppressive tumour microenvironment.
Explore the acute metabolic effects of immune cell stimulation using real-time activation assays.
Immune cell activation stimulates an increased energetic demand, driving a rapid switch towards anabolic pathways required to produce and secrete cytokines and increase cell proliferation. XF analysis can be used to assess immune cell activation in minutes. This allows for real-time metabolic outputs to be measured such as ATP supply flux, bioenergetic capacity and metabolic flexibility.
Enhance cell performance by measuring and modulating immune cell fate, fitness, and function
Activation, amplification, engagement of effector functions, and return to homeostasis are all crucial aspects of the immune cell life cycle. XF analysis provides real-time functional measurements for a comprehensive picture of immune cell function and insights into pathways and targets to modulate immune cell responses.
Discover strategies to perturb pathways and control immune cell response to advance therapeutic outcome.
Immune cell-based therapy is a method that aims to enhance the performance of native immune cells by modifying immune cell biology. Measurement of real-time cellular metabolism using XF analysis provides important insights of metabolic programming during modulation of immune cell responses via signalling, checkpoint blockade, or pathway perturbation.
Explore even more with our cell metabolism assays
Optimise methods for cell manufacturing.
Develop safe, effective immunotherapy products using cell engineering strategies.
Enhance antitumor immunity through immune cell checkpoint blockade strategies.
Make informed decisions about potential therapeutic targets.
Monitoring efficacy and safety immuotoxicity of your drugs.
Our immune cell metabolism assays
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BioCELL mitoTOX
Probe real-time, direct measurements of mitochondrial metabolism with high sensitivity and specificity. Our solution for high-throughput compound screening.
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BioCELL proFILE
An all-in-one solution to metabolically profile cells using real-time measurements of mitochondrial and glycolytic energy metabolism.
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BioCELL actiVATION
Explore the energetic switches that occur in real-time upon immune cell stimulation with our cell activation assays.
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BioCELL mitoTEST
This assay provides key insights into mitochondrial function and used to investigate functional differences among cell types, drug candidates, and genetic or biochemical interventions.
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BioCELL glycoTEST
A precise measure of glycolysis in living intact cells, revealing transient responses and rapid metabolic switches not discernible in end-point lactate assays.